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Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
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Common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis

P Coto-Segura1,2, D González-Fernández1, A Batalla1

  • 1Department of Dermatology, Hospital Universitario Central Asturias, Oviedo, Spain.

The British Journal of Dermatology
|February 9, 2016
PubMed

Insights

Specific CARD14 gene variants may influence patient response to anti-tumour necrosis factor (anti-TNF) therapies for psoriasis. The common p.Arg820Trp variant and rare missense variants were linked to better treatment outcomes.

Area of Science:

  • Genetics and immunology
  • Dermatology
  • Pharmacogenomics

Background:

  • The CARD14 gene is implicated in inflammatory pathways and psoriasis development.
  • CARD14 variants are associated with psoriasis risk.
  • This study investigates CARD14 variants' role in anti-TNF therapy response.

Purpose of the Study:

  • To determine if CARD14 gene variants correlate with positive responses to anti-tumour necrosis factor (anti-TNF) therapies in psoriasis patients.

Main Methods:

  • Next-generation sequencing of the CARD14 gene in 116 psoriasis patients.
  • Analysis of allele and genotype frequencies in responders versus non-responders.

Main Results:

  • A common CARD14 variant, rs11652075 CC (p.Arg820Trp), was significantly more frequent in responders (P = 0.01).
  • Rare CARD14 variants (p.Glu422Lys and p.Arg682Trp) were also observed more frequently in responders.

Conclusions:

  • The CARD14 p.Arg820Trp variant may significantly impact anti-TNF therapy effectiveness in psoriasis.
  • Rare CARD14 missense variants might also predict a better response to these therapies.
Abstract

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