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3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
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Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies:

D J Cohen1, A Cheng2,3, A Kahn4

  • 1Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, U.S.A.

Scientific Reports
|February 9, 2016
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Summary
This summary is machine-generated.

Novel 3D-printed titanium devices with textured surfaces promote significant bone regeneration and dental implant stability in patients with severe jawbone loss. These custom implants enhance osseointegration for better outcomes in complex cases.

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Dental Implantology

Background:

  • Edentulous patients with significant mandibular deficiencies often cannot receive traditional endosteal implants.
  • A need exists for custom bone regeneration devices to support dental implant placement in these challenging cases.

Purpose of the Study:

  • To develop and evaluate a novel, patient-specific, additively manufactured subperiosteal bone onlay device with a surface-modified texture for enhanced bone regeneration and dental implant support.

Main Methods:

  • Additive manufacturing (AM) of titanium-aluminum-vanadium onlay devices with micro-/nano-scale surface texturing.
  • In vitro studies using human osteoblasts on textured vs. smooth surfaces.
  • In vivo studies in rat calvaria and rabbit tibias to assess bone-implant contact, bone growth, osseointegration, and mechanical stability.
  • Clinical implantation of patient-specific devices in edentulous patients.

Main Results:

  • Textured surfaces stimulated osteoblasts to produce osteogenic and angiogenic factors.
  • Surface-modified constructs demonstrated significantly higher bone-to-implant contact, vertical bone growth, and pull-out force in rat models.
  • Wrap-implants showed successful osseointegration in rabbit tibias within 6 weeks.
  • Clinical application showed new bone formation, device osseointegration, and dental implant stability at 3 and 8 months post-surgery.

Conclusions:

  • Additively manufactured, surface-textured subperiosteal implants represent a promising solution for bone regeneration and dental implant support in patients with severe mandibular deficiencies.
  • The developed technology enhances osseointegration and bone formation, enabling stable dental implant placement where conventional methods are not feasible.