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Updated: Mar 26, 2026

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Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging
Published on: December 8, 2023
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Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors
Ying Tang1, Zhan Wu1, Chong-Hua Zhang1
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn zhanwu@hnu.edu.cn.
Abstract:
We developed novel activatable probe using self-assembled peptide nanowires with low affinity and toxicity to tumor cells in the absence of matrix metalloproteinase that showed activated high affinity and toxicity and provided a highly selective and efficient platform for targeted therapy and tumor imaging.

