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Development of a small single-ring OpenPET prototype with a novel transformable architecture.

Hideaki Tashima1, Eiji Yoshida, Naoko Inadama

  • 1Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

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A novel transformable single-ring OpenPET (SROP) prototype enables in-beam PET imaging. This axial-shift SROP minimizes performance loss by switching between open and closed modes, crucial for particle therapy applications.

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Area of Science:

  • Medical Physics
  • Nuclear Instrumentation
  • Positron Emission Tomography

Background:

  • In-beam Positron Emission Tomography (PET) is vital for real-time monitoring during particle therapy.
  • Conventional cylindrical PET scanners pose limitations for in-beam applications due to geometric constraints.

Purpose of the Study:

  • To develop and evaluate a proof-of-concept prototype for an axial-shift single-ring OpenPET (AS-SROP) with a transformable architecture.
  • To assess the feasibility of in-beam PET imaging using the AS-SROP prototype.

Main Methods:

  • Designed a small AS-SROP prototype with 4-layer depth-of-interaction detectors in a 250 mm diameter ring.
  • Implemented a transformable architecture allowing switching between an 'open' mode (SROP) and a 'closed' mode (conventional PET).
  • Conducted in-beam imaging tests using (11)C radioactive beam irradiation at HIMAC.

Main Results:

  • The open mode facilitated in-beam PET imaging with a spatial resolution of 2.6 mm and sensitivity of 5.1%.
  • The closed mode achieved better performance with a spatial resolution of 2.1 mm and sensitivity of 7.3%.
  • The AS-SROP demonstrated a minimal decrease in imaging performance when transitioning between modes.

Conclusions:

  • The AS-SROP prototype successfully enables in-beam PET imaging.
  • The transformable design allows for optimized performance by switching to closed mode post-irradiation.
  • AS-SROP offers a promising solution for in-beam PET applications, balancing imaging capabilities with detector accessibility.