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Updated: Mar 26, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Detection of bone marrow involvement in newly diagnosed post-transplant lymphoproliferative disorder:

Olivier Gheysens1, Sanne Thielemans1, Julie Morscio2

  • 1a Nuclear Medicine and Molecular Imaging, University Hospitals Leuven, Belgium and Department of Imaging and Pathology, KU Leuven , Belgium ;

Leukemia & Lymphoma
|February 9, 2016
PubMed

Detecting bone marrow involvement (BMI) in lymphoma is important as it adversely affects stage. Bone marrow biopsy (BMB) remains the standard to detect BMI but is prone to sampling error. We retrospectively investigated whether (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG-PET/CT) could identify BMI in patients with post-transplant lymphoproliferative disorder (PTLD) with sufficient accuracy in comparison with staging BMB. Twenty-five patients diagnosed with PTLD who underwent (18)F-FDG-PET/CT and BMB within one month were evaluated. Based on our criteria, six patients (24%) were considered positive for BMI on (18)F-FDG-PET/CT compared to one by BMB. Although we cannot completely exclude false positive results on (18)F-FDG-PET/CT, our data indicate a significantly higher sensitivity of (18)F-FDG-PET/CT compared to BMB (100% vs 17%) but similar specificity. These data confirm the high diagnostic performance of (18)F-FDG-PET/CT for detecting BMI, but prospective studies are needed to determine whether (18)F-FDG-PET/CT could indeed replace staging BMB in PTLD.

Keywords:
Bone marrow biopsyFDG-PET/CTPTLDpost-transplant lymphoproliferative disordertransplantation

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