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Updated: Mar 26, 2026
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Chorioamnionitis and Neurocognitive Development at Age 2 Years.
Emilie Vander Haar1, Cynthia Gyamfi-Bannerman
1Division of Maternal-Fetal Medicine and the Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York.
Obstetrics and Gynecology
|February 9, 2016
Summary
Chorioamnionitis, an infection during pregnancy, did not show a link to lower neurodevelopmental scores in children at age two. This study found no association between maternal infection and cognitive or psychomotor deficits.
Area of Science:
- Perinatal Medicine
- Neurodevelopmental Pediatrics
- Infectious Diseases in Pregnancy
Background:
- Chorioamnionitis is a common complication in high-risk pregnancies.
- Understanding its long-term effects on offspring neurodevelopment is crucial.
Purpose of the Study:
- To investigate the association between chorioamnionitis and neurodevelopmental outcomes at age two.
- To determine if chorioamnionitis impacts Bayley II scores.
Main Methods:
- Observational cohort study of 1,574 mother-infant pairs from a trial for cerebral palsy prevention.
- Exposure: clinical chorioamnionitis with maternal fever.
- Outcome: Bayley II Mental Developmental Index (MDI) or Psychomotor Developmental Index (PDI) scores < 70 or < 85 at 2 years.
Main Results:
- 12% of mothers had chorioamnionitis; mean gestational age was 29 3/7 weeks.
- No significant difference in MDI or PDI scores < 70 between children exposed or not exposed to chorioamnionitis.
- Adjusted analyses also showed no association; however, sepsis diagnosis was linked to lower MDI scores.
Conclusions:
- Chorioamnionitis exposure was not associated with neurocognitive defects as measured by abnormal Bayley II scores at age two.
- Findings suggest chorioamnionitis itself may not be a direct cause of impaired neurodevelopment in this cohort.
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