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Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Mar 26, 2026

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation

Published on: August 18, 2016

The three-dimensional cancer genome.

M Ryan Corces¹, Victor G Corces²

¹Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA.

Current Opinion in Genetics & Development

|February 9, 2016

Summary

This summary is machine-generated.

The three-dimensional (3D) genome topology, once overlooked, is now recognized as crucial in cancer development. Disruptions in chromatin organization significantly impact tumorigenesis and are a hallmark of many cancer subtypes.

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Last Updated: Mar 26, 2026

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation

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Published on: August 18, 2016

Three-Dimensional 3D Tumor Spheroid Invasion Assay

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Published on: May 1, 2015

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Published on: October 26, 2013

Area of Science:

Genomics
Cancer Biology
Epigenetics

Background:

Recent cancer research has focused on genomic alterations during tumorigenesis.
The epigenome and three-dimensional (3D) chromatin topology are newly implicated in cancer progression.

Purpose of the Study:

To review recent findings on how the cancer genome is regulated and dysregulated.
To discuss the impact of 3D genome topology on cancer development.

Main Methods:

Literature review of recent findings in cancer genomics and epigenetics.
Analysis of the role of 3D genome organization in tumorigenesis.

Main Results:

The spatial organization of the genome influences the frequency of chromosomal translocations.
Disruption of proteins forming chromatin loops affects cancer progression.
Alterations in 3D cancer genome topology are a hallmark of multiple cancer subtypes.

Conclusions:

The epigenome and 3D genome topology play a significant role in cancer progression.
Understanding 3D genome alterations is critical for advancing cancer research and treatment.