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Biomechanical Testing of Murine Tendons

Biomechanical Testing of Murine Tendons

Published on: October 15, 2019

Modelling approaches for evaluating multiscale tendon mechanics.

Fei Fang¹, Spencer P Lake²

¹Department of Mechanical Engineering and Materials Science , Washington University in St Louis , St Louis, MO 63130 , USA.

Interface Focus

|February 9, 2016

Summary

This summary is machine-generated.

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This review explores mathematical and computational models of tendon mechanics across hierarchical scales. Multiscale modeling is proposed to better understand tendon

Area of Science:

Biomechanics
Computational modeling
Tendon structure-function relationships

Background:

Tendon mechanical properties are anisotropic, inhomogeneous, and viscoelastic due to complex hierarchical structures.
Existing models often fail to integrate across length scales or clarify the roles of minor constituents.

Purpose of the Study:

To review mathematical and computational models used to understand tendon mechanics at various hierarchical levels.
To highlight the potential of multiscale modeling for elucidating tendon structure-function relationships.

Main Methods:

Discussion of models at molecular, fibril, and tissue levels.
Inclusion of phenomenological and microstructural modeling approaches.
Evaluation of crimp, helical structure, and collagen-proteoglycan interactions.

Keywords:

computational modelling mathematical modelling mechanical properties multiscale tendon

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Main Results:

Review of diverse modeling strategies for tendon mechanics.
Identification of gaps in current understanding, particularly regarding minor components and cross-scale integration.
Proposal of multiscale modeling as a key methodology.

Conclusions:

Multiscale modeling offers an advantageous approach to understanding tendon mechanics.
Further research integrating different scales is crucial for comprehending tendon adaptation to in vivo loading.