Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...

Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Surface Tension of Fluid

Surface Tension of Fluid

Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies...

Surface Tension and Surface Energy

Surface Tension and Surface Energy

When a paint brush is immersed in water, the bristles wave freely inside the water. When it is taken out, the bristles stick together. The reason behind this effect is surface tension.
Consider a beaker filled with liquid. The bulk molecules in the liquid experience equal attractive forces on all sides with the surrounding molecules. However, the surface molecules experience a net attractive force downward due to the bulk molecules. The surface of the liquid behaves like a stretched membrane,...

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Mechanical Protein Functions

Mechanical Protein Functions

Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Grafts in tendon repair.

Materials today. Bio·2026

Same author

Surface-Biofunctionalized Dual-Purpose Scaffolds that Minimize Growth Factor Dependency for Stem Cell Expansion and Delivery.

ACS applied materials & interfaces·2025

Same author

Cross-Linked Zwitterionic Surface Modifications for Biocompatible Blood-Contacting Medical Devices.

Advanced healthcare materials·2025

Same author

In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators.

British journal of pharmacology·2025

Same author

Bioprinting vascularized skin analogs: a stepwise approach.

Burns & trauma·2025

Same author

Sheep femoral artery occlusion is well tolerated and does not result in ischemia.

Animal models and experimental medicine·2025

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Force fields for simulating the interaction of surfaces with biological molecules.

Lewis Martin¹, Marcela M Bilek¹, Anthony S Weiss²

¹Department of Applied Physics , University of Sydney , Sydney, New South Wales , Australia.

Interface Focus

|February 9, 2016

Summary

Developing accurate molecular models for peptide-surface interactions is crucial for biotechnologies. This research focuses on creating a non-polarizable model to understand peptide binding mechanisms and conformational changes at biointerfaces.

Keywords:

biointerface molecular dynamics parametrization peptide surface

More Related Videos

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Published on: November 20, 2021

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

Related Experiment Videos

Last Updated: Mar 26, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Molecular Spring Constant Analysis by Biomembrane Force Probe Spectroscopy

Published on: November 20, 2021

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Taking Advantage of Reduced Droplet-surface Interaction to Optimize Transport of Bioanalytes in Digital Microfluidics

Published on: November 10, 2014

Area of Science:

Biomolecular interactions
Surface science
Computational chemistry

Background:

Peptide-surface interactions are vital for biotechnologies like medical implants and diagnostics.
Current experimental methods lack the resolution to fully understand peptide binding mechanisms and conformational changes.
Existing nanoscale simulation models are primarily for aqueous environments, not biointerfaces.

Purpose of the Study:

To review research on developing a non-polarizable molecular model for peptide-surface interactions.
To address the need for accurate models describing biointerfaces.
To provide insights into peptide binding mechanisms and conformational effects at solid interfaces.

Main Methods:

Focus on developing a non-polarizable molecular model for peptide-surface interactions.
Detailing the process of fitting model parameters.
Discussing validation strategies using experimental data.

Main Results:

Progress in developing a non-polarizable molecular model for peptide-surface interactions.
Identification of key considerations for parameter fitting and model validation.
Highlighting the potential of nanoscale simulations for biointerface research.

Conclusions:

A non-polarizable molecular model is essential for understanding peptide-surface interactions.
Further research and validation are needed to refine models for biointerface applications.
Nanoscale simulations offer a promising avenue for advancing biointerface science and technology.