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Related Experiment Videos

[Kidney involvement in autoimmune diseases].

O Mehls1, D E Müller-Wiefel, A M Wingen

  • 1Sektion für Pädiatrische Nephrologie, Universitäts-Kinderklinik Heidelberg.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|October 1, 1989
PubMed
Summary

Effective treatments for autoimmune kidney diseases like Goodpasture's syndrome, Wegener's disease, and lupus are improving patient survival. Early diagnosis and tailored therapies, including immunosuppressants and plasmapheresis, are crucial for managing renal involvement.

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Desperately seeking diarrhoea: outbreak of haemolytic uraemic syndrome caused by emerging sorbitol-fermenting shiga toxin-producing Escherichia coli O157:H-, Germany, 2009.

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Response to GH in chronic renal failure. Prediction and treatment strategies.

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Differential regulation of RGS-2 by constant and oscillating PTH concentrations.

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Der Urologe. Ausg. A·2006

Area of Science:

  • Nephrology
  • Immunology
  • Rheumatology

Context:

  • Generalized immune diseases frequently involve renal complications, impacting patient prognosis.
  • Understanding the pathogenesis, diagnosis, and treatment of these conditions is critical for effective patient management.

Purpose:

  • To report new aspects of pathogenesis, diagnosis, and treatment for renal involvement in classic generalized immune diseases.
  • To outline current therapeutic strategies and their efficacy in specific autoimmune renal diseases.

Summary:

  • Goodpasture's syndrome: High-dose corticosteroids, cyclophosphamide pulse therapy, and plasmapheresis improve survival; renal transplantation is feasible after autoantibody cessation.
  • Wegener's disease: Prompt treatment is vital; long-term cyclophosphamide can induce remission, aided by autoantibody detection assays.

Related Experiment Videos

  • Systemic lupus erythematosus: Renal biopsy guides high-dose steroid use in diffuse proliferative glomerulonephritis; cyclophosphamide may slow progression, while plasmapheresis efficacy is unproven. Cyclosporin A reduces steroid dosage.

    • Impact:

    • Improved survival rates and treatment options for patients with autoimmune-induced kidney disease.
    • Enhanced diagnostic capabilities through autoantibody detection assays.
    • Personalized treatment approaches based on specific disease and renal pathology, optimizing therapeutic outcomes.