Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

107
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
107

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Anti-transforming growth factor-β treatment shows increased bone mass and strength in a novel mouse model for osteogenesis imperfecta type I.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same author

Artificial intelligence for direct-to-physician reporting of ambulatory electrocardiography.

Nature medicine·2025
Same author

Long-Lived Magnetization in an Atomic Spin Chain Tuned to a Diabolic Point.

Physical review letters·2024
Same author

Effect of total cholesterol level variabilities on cerebrovascular disease.

European review for medical and pharmacological sciences·2022
Same author

Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

Physical review letters·2021
Same journal

Crosslinker-free PVA hydrogel incorporating a water-soluble Ir(III) photosensitizer for antibacterial photodynamic applications in wound healing.

Journal of materials chemistry. B·2026
Same journal

Precise microfluidic engineering of mRNA lipid nanoparticle-loaded polycaprolactone microcapsules for sustained delivery.

Journal of materials chemistry. B·2026
Same journal

Multifunctional polysulfone/strontium silicate composites with tunable properties through silane functionalization.

Journal of materials chemistry. B·2026
Same journal

Melanocortin 1 receptor-targeted peptide-functionalized liposomes for enhanced melanocyte-preferential drug delivery and anti-melanogenic efficacy.

Journal of materials chemistry. B·2026
Same journal

Recent progress in side-chain amino acid-based polymers: synthesis, self-assembly, and emerging biomedical applications.

Journal of materials chemistry. B·2026
Same journal

Bioinspired electrospun nanofibrous dressings loaded with Mentha-derived exosome-like vesicles for antibacterial and immunomodulatory burn healing.

Journal of materials chemistry. B·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.7K

Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer.

M Dickerson1, B Howerton2, Y Bae2

  • 1Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.

Journal of Materials Chemistry. B
|February 9, 2016
PubMed
Summary
This summary is machine-generated.

Cross-linked nanoassemblies improve photoactivatable ruthenium complexes for photodynamic therapy. This delivery method enhances efficacy while reducing DNA interactions, though release mechanisms require further investigation.

More Related Videos

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

6.7K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

9.5K

Area of Science:

  • Materials Science
  • Chemistry
  • Biomedical Engineering

Background:

  • Photoactivatable ruthenium complexes show promise for photodynamic therapy (PDT).
  • Developing effective delivery systems is crucial for enhancing their therapeutic efficacy and minimizing off-target effects.
  • Cross-linked nanoassemblies (CNAs) offer a potential strategy for controlled drug delivery.

Purpose of the Study:

  • To investigate the use of cross-linked nanoassemblies (CNAs) for delivering photoactivatable ruthenium complexes.
  • To analyze the impact of complex properties and environmental factors on CNA loading and release kinetics.
  • To evaluate the cytotoxicity and DNA interaction of CNA-encapsulated complexes compared to free complexes.

Main Methods:

  • Synthesis and characterization of cross-linked nanoassemblies (CNAs).
  • Loading of photoactivatable ruthenium complexes into CNAs.
  • Analysis of complex release kinetics under varying hydrophobicity, ionic strength, and pH.
  • Assessment of cell cytotoxicity using standard assays.
  • Evaluation of DNA interaction using spectroscopic methods.

Main Results:

  • Complex loading and release from CNAs were influenced by photoactivation, hydrophobicity, ionic strength, and pH.
  • Release rate and extent of Ru complex release varied inversely with complex hydrophobicity.
  • CNA formulations exhibited similar cytotoxicity to free Ru complexes but with reduced DNA interactions.
  • Incomplete release of some complexes from CNAs after 48 hours complicated the interpretation of results.

Conclusions:

  • Cross-linked nanoassemblies (CNAs) represent a viable delivery strategy for photoactivatable ruthenium complexes in photodynamic therapy.
  • CNAs can modulate the release kinetics and reduce DNA interactions of ruthenium complexes.
  • Further research is needed to elucidate the precise release mechanisms and optimize CNA formulations for enhanced therapeutic outcomes.