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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Mar 26, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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GENETICS OF HUMAN AGE RELATED DISORDERS.

I Srivastava, N Thukral, Y Hasija

    Advances in Gerontology = Uspekhi Gerontologii
    |February 10, 2016
    PubMed
    Summary

    Genetic predisposition significantly influences aging and age-related disorders (ARDs). Key genes like APOE and BDNF are implicated, highlighting common genetic variants in ARD causation for future research.

    Area of Science:

    • Genetics
    • Gerontology
    • Molecular Biology

    Background:

    • Aging is a natural process, but it accelerates the incidence of age-related disorders (ARDs).
    • ARDs pose a significant socioeconomic challenge, with the elderly population projected to reach 2 billion by 2050.
    • Genetic associations, identified through genome-wide association studies (GWAS), reveal a substantial genetic contribution to aging and ARDs.

    Purpose of the Study:

    • To review the current understanding of how genetic predisposition influences the aging process.
    • To identify key genes and pathways associated with multiple ARDs.
    • To explore the potential of common genetic variants in understanding ARD biology.

    Main Methods:

    • Literature review focusing on genetic association studies and GWAS.

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  • Pathway analysis to identify genes linked to multiple ARDs.
  • Network analysis to explore interconnections between genes involved in ARDs.

    • Main Results:

    • Several genes, including apolipoprotein E (APOE), brain-derived neurotrophic factor (BDNF), and methylenetetrahydrofolate reductase (MTHFR), are associated with multiple ARDs.
    • These genes are significantly enriched in pathways such as Jak-STAT signaling, asthma, and allograft rejection.
    • Network analysis highlighted interconnections between interleukin-6 (IL-6), insulin (INS), and vascular endothelial growth factor A (VEGFA), among others.

    Conclusions:

    • Common genetic variants play a pivotal role in the causation of various ARDs.
    • Understanding these shared genetic underpinnings is crucial for advancing research into ARD biology.
    • Further investigation into common genetic variants could lead to novel insights into aging and disease prevention.