[STRESS- AND GERO PROTECTIVE PROPERTIES OF 20-HYDROXYECDYSONE AND ITS DERIVATIVES]

The long-term stress protective effects have been revealed among newly synthesized 9α-hydroxy-5α-ecdysteroids via a short-term heat stress tests (housefly Musca domestica). An increase as well as a reduce of protective effects for synthesized compounds have been demonstrated in comparison with the reference ecdysteroid 20-hydroxyecdysone, which obtained from the juice of Serratula coronata. The interdependence between stress- and geroprotective properties of the test models with their genotypic features and the structure of ecdvsteroids has been established.