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Updated: Mar 26, 2026
04:41
Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
Published on: January 9, 2020
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[GENETIC AND EPIGENETIC DETERMINANTS OF ALZHEIMER'S DISEASE]
Advances in Gerontology = Uspekhi Gerontologii
|February 10, 2016
Summary
Genetic and epigenetic factors significantly influence Alzheimer's disease (AD) risk and development. Polymorphisms in the APOE gene are key genetic risk factors for AD.
Area of Science:
- Neuroscience
- Genetics
- Epigenetics
Context:
- Alzheimer's disease (AD) presents a major global challenge.
- Genetic and epigenetic factors are increasingly recognized in AD etiology.
Purpose:
- To review recent research on genetic and epigenetic contributions to Alzheimer's disease.
- To discuss the role of specific gene variants, like APOE, in AD pathogenesis.
Summary:
- The review highlights studies linking genetic variations, particularly APOE polymorphisms, to increased AD risk.
- Epigenetic modifications are also discussed as crucial factors in the development and progression of Alzheimer's disease.
Impact:
- Understanding genetic and epigenetic factors is vital for developing targeted AD therapies.
- This knowledge advances the fields of neurodegenerative disease research and personalized medicine.
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