Related Experiment Video
Updated: Mar 26, 2026
06:51
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
16.1K
Immunotherapy in Chronic Lymphocytic Leukaemia (CLL)
Ciara L Freeman1, John G Gribben2
1John Vane Cancer Centre, Charterhouse Square, Barts Cancer Institute, Queen Mary University of London, London, UK. c.freeman@qmul.ac.uk.
Current Hematologic Malignancy Reports
|February 10, 2016
Summary
Immunotherapy offers a promising approach for chronic lymphocytic leukemia (CLL) due to the disease's immune evasion and patient co-morbidities. This review explores current and future immunotherapies for CLL.
Area of Science:
- Oncology
- Immunology
Background:
- Chronic lymphocytic leukemia (CLL) impairs host immune responses.
- CLL cells reside in vascularized tissues and blood, near effector cells.
- Older patients with co-morbidities often cannot tolerate traditional chemotherapy for CLL.
Purpose of the Study:
- To review past and present immunotherapies for CLL.
- To discuss the potential evolution of CLL immunotherapy.
Main Methods:
- Literature review of immunotherapy in CLL.
- Analysis of clinical outcomes and mechanisms of action.
Main Results:
- Immunotherapy, including monoclonal antibodies like rituximab, has shown significant efficacy in CLL.
- Harnessing immune-mediated responses is effective in managing CLL.
Conclusions:
- CLL is an ideal candidate for immunotherapy development.
- Immunotherapy represents a key strategy for managing CLL, with ongoing advancements expected.
Related Concept Videos
01:27Tumor Immunotherapy
2.2K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.2K
02:57Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K
02:50Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K