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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network.

W S Bush1, D R Crosslin2, A Owusu-Obeng3

  • 1Case Western Reserve University, Cleveland, Ohio, USA.

Clinical Pharmacology and Therapeutics
|February 10, 2016
PubMed
Summary

Rare genetic variants significantly impact drug response. The eMERGE-PGx study found actionable pharmacogenetic variants in most participants, highlighting challenges for precision medicine implementation.

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