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CASP11 statistics and the prediction center evaluation system.

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The Critical Assessment of protein Structure Prediction (CASP) experiments were updated with new evaluation systems and infrastructure for CASP11 and CASP ROLL. These enhancements improve protein structure prediction assessments.

Keywords:
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Area of Science:

  • Computational biology
  • Structural biology
  • Bioinformatics

Background:

  • The Protein Structure Prediction Center (predictioncenter.org) has historically organized the CASP experiments.
  • CASP provides a framework for assessing the accuracy of protein structure prediction methods.

Purpose of the Study:

  • To describe the role of the Protein Structure Prediction Center in CASP11 and CASP ROLL.
  • To detail the infrastructure and evaluation system changes implemented for these experiments.

Main Methods:

  • Overview of the CASP infrastructure and its expansion.
  • Implementation of a comprehensive evaluation system with statistical tests and visualization tools.
  • Redesign of the assessors' web-workspace for multi-measure assessments.

Main Results:

  • CASP11 and CASP ROLL incorporated an expanded evaluation system and infrastructure.
  • New categories for contact-assisted and multimeric predictions were introduced.
  • The assessors' workspace was enhanced for more detailed and flexible assessments.

Conclusions:

  • The updated CASP infrastructure and evaluation system enhance the assessment of protein structure prediction.
  • These improvements facilitate more rigorous and comprehensive evaluations of prediction methods.