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Published on: February 5, 2019
Health outcomes of neonates with osteogenesis imperfecta: a cross-sectional study
Doris P Yimgang1, Evelise Brizola1,2, Jay R Shapiro1
1a Bone and Osteogenesis Imperfecta Department, Kennedy Krieger Institute, Johns Hopkins School of Medicine , Baltimore , MD , USA and.
Insights
Neonates with osteogenesis imperfecta (OI) face high risks of skeletal disorders, preterm birth, and breech presentation. Younger maternal age and preterm delivery predict the need for neonatal intensive care unit (NICU) admission.
Area of Science:
- Perinatal Medicine
- Genetics
- Neonatology
Background:
- Osteogenesis imperfecta (OI) is a group of genetic disorders characterized by fragile bones.
- Understanding at-birth health outcomes in neonates with OI is crucial for timely intervention and improved care.
- Previous research has focused on long-term management, with less emphasis on immediate neonatal health challenges.
Purpose of the Study:
- To evaluate the at-birth health status and complications in newborns diagnosed with osteogenesis imperfecta (OI).
- To identify risk factors associated with adverse neonatal outcomes in infants with OI.
- To inform clinical practice regarding the management of pregnant women with OI and their neonates.
Main Methods:
- A survey was administered to 53 mothers reporting at least one child with OI.
- Data collected included pregnancy duration, neonatal intensive care unit (NICU) admission, birth complications, and infant clinical details (OI type, physical measurements).
- Statistical analysis was performed to identify associations between maternal and neonatal factors and outcomes.
Main Results:
- The study analyzed data from 77 neonates with OI (60 type I, 4 type III, 13 type IV).
- Common at-birth conditions included breech presentation (24%), prematurity (27%), fractures (18%), bone deformities (18%), and respiratory issues (22%).
- Thirty-one percent of neonates required NICU care, with younger maternal age and preterm delivery significantly associated with NICU admission.
Conclusions:
- Newborns with OI exhibit a high prevalence of skeletal disorders, preterm birth, and breech presentation.
- Younger maternal age and preterm delivery are significant predictors for NICU admission in infants with OI.
- Pregnant women with OI, especially those under 20, may require enhanced clinical supervision to anticipate and manage potential adverse neonatal outcomes.
Objective:
To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI).
Study Design:
A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child's clinical information including OI type, height and weight.
Results:
Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission.
Conclusion:
Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
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