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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Systemic lupus erythematosus. How to manage this chronic, complicated disorder
1Department of Family Practice, University of Louisville School of Medicine, KY 40292.
Abstract:
Systemic lupus erythematosus is an autoimmune disease of unknown cause characterized by exacerbations and remissions. Disease manifestations are diverse, but the most common symptoms are fatigue, fever, weight loss, skin rash, arthritis or arthralgias, and anemia. Clinical findings and measurement of antibody titers are the most common diagnostic criteria. Individualized therapy with corticosteroids, immunosuppressives, or antimalarial agents and careful monitoring of disease activity are essential.
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