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Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
Published on: March 8, 2019
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Abdominal aortic aneurysm and histological, clinical, radiological correlation
Luigi Fabrizio Rodella1, Rita Rezzani1, Francesca Bonomini1
1Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, V.le Europa 11, 25123, Brescia, Italy.
Acta Histochemica
|February 10, 2016
Summary
Abdominal aortic aneurism (AAA) involves structural changes in the aorta, with increased type I collagen and nerve/vascular structures. The adventitia plays a key role, showing inflammatory infiltration in AAA pathogenesis.
Area of Science:
- Vascular Biology
- Pathology
- Biochemistry
Background:
- The pathogenesis of abdominal aortic aneurism (AAA) remains incompletely understood.
- Evaluating structural alterations in the aorta is crucial for understanding AAA development.
Purpose of the Study:
- To investigate changes in aortic structure during abdominal aortic aneurism (AAA).
- To analyze the collagen composition and vascular/nerve structures within the aorta in AAA.
Main Methods:
- Microscopic analysis of AAA vessel sections using Verhoeff-Van Gieson, Masson Goldner, and Sirius Red staining.
- Quantification of type I and type III collagen, vasa vasorum (CD34+), and nerva vasorum (PGP 9.5+).
- Correlation of structural changes with cardiovascular risk factors and radiological data.
Main Results:
- AAA samples showed increased type I collagen and decreased type III collagen in the tunica media and adventitia.
- Higher amounts of vasa vasorum and nerva vasorum were observed in AAA tissues.
- Cardiovascular risk factors and radiological findings exacerbated these structural changes.
Conclusions:
- The tunica adventitia appears to play a significant role in AAA pathogenesis, characterized by inflammatory infiltration.
- Immune components within the aorta contribute to the structural modifications observed in AAA.
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