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[Indications for therapy using MAO inhibitors].

M Schmauss1, A Erfurth

  • 1Psychiatrische Klinik der Universität München.

Psychiatrische Praxis
|August 1, 1989
PubMed
Summary
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Monoamine oxidase inhibitors (MAOIs) are effective for anxiety and depression but are underutilized due to exaggerated fears. With proper precautions, MAOIs offer a valuable treatment option for various psychiatric disorders.

Area of Science:

  • Psychiatry
  • Pharmacology

Context:

  • Monoamine oxidase inhibitors (MAOIs) are a class of psychoactive drugs.
  • These drugs are underutilized due to a historical fear of their side effects and toxicity.
  • MAOIs have demonstrated efficacy across a spectrum of psychiatric conditions.

Purpose:

  • To reassess the utility and safety profile of monoamine oxidase inhibitors (MAOIs).
  • To highlight the therapeutic potential of MAOIs in treating anxiety and depressive disorders.
  • To address and correct common misconceptions regarding MAOI-associated risks.

Summary:

  • MAOIs are effective for anxiety disorders, particularly those with phobic or panic symptoms.
  • They are also beneficial for melancholic depression, especially in outpatients with low energy, bipolar history, or TCA non-response.

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  • Their primary utility lies in treating ambulatory depressives with mixed anxiety-depression symptoms.
  • The risks, including hypertensive crisis, are often exaggerated and manageable through dietary adherence and dose adjustment.
  • Selective and reversible MAOIs may offer an improved safety profile over classical agents.
  • Impact:

    • MAOIs represent a valuable, albeit underutilized, therapeutic option for a range of psychiatric disorders.
    • Understanding their manageable risks can encourage wider clinical adoption.
    • This review aims to re-establish MAOIs as a viable treatment in psychiatric pharmacotherapy.