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Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
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Human Motor Cortex Functional Changes in Acute Stroke: Gender Effects.

Vincenzo Di Lazzaro1, Giovanni Pellegrino2, Giovanni Di Pino1

  • 1Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di RomaRome, Italy; Fondazione Alberto Sordi - Research Institute for AgeingRome, Italy.

Frontiers in Neuroscience
|February 10, 2016
PubMed
Summary
This summary is machine-generated.

Gender significantly impacts brain excitability changes after acute stroke. Intermittent theta burst stimulation (iTBS) effects and hemispheric asymmetry differ between males and females, informing personalized stroke recovery strategies.

Keywords:
acute cerebral infarctiongenderneurophysiologystroketranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Stroke induces functional brain changes, affecting interhemispheric interplay.
  • In healthy individuals, gender influences brain organization and function.
  • Understanding gender-specific stroke adaptations is crucial for effective rehabilitation.

Purpose of the Study:

  • To investigate if gender influences functional brain changes during the acute phase of ischemic stroke.
  • To compare hemispheric excitability and asymmetry between male and female stroke patients.
  • To explore gender-based differences in response to non-invasive brain stimulation.

Main Methods:

  • Assessed thirty-five ischemic stroke patients.
  • Measured resting motor threshold (RMT) and active motor threshold (AMT) in affected (AH) and unaffected hemispheres (UH).
  • Applied intermittent theta burst stimulation (iTBS) to the AH and calculated laterality indexes (LI) for hemispheric asymmetry.

Main Results:

  • Hemispheric differences in AMT were significant in males but not females.
  • Male stroke patients exhibited higher LI for both RMT and AMT compared to females.
  • Long-term potentiation (LTP)-like plasticity induced by iTBS was more prevalent in female patients.

Conclusions:

  • Gender plays a significant role in acute stroke-related functional excitability changes and hemispheric asymmetry.
  • Differences in neuroplasticity, such as LTP induction, are gender-dependent post-stroke.
  • Tailoring non-invasive brain stimulation strategies to gender may enhance stroke recovery outcomes.