Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of a factor Xa inhibitor (apixaban) on SIV pathogenesis and response to antiretroviral therapy.

JCI insight·2026

Same author

The deadly triple M (mistrust, misinformation, and missed opportunities): understanding Romania's COVID-19 vaccination campaign and its lasting impact on public health.

Frontiers in public health·2025

Same author

Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques.

The Journal of clinical investigation·2025

Same author

The heart of the matter: modeling HIV-associated cardiovascular comorbidities in nonhuman primate models.

Frontiers in cellular and infection microbiology·2025

Same author

Plasma lipidomic alterations during pathogenic SIV infection with and without antiretroviral therapy.

Frontiers in immunology·2025

Same author

It's all in the gut: the central role of the gut and microbiome in preventing disease progression in simian immunodeficiency viruses infected African nonhuman primates.

Current opinion in HIV and AIDS·2025

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Animal Models for HIV Cure Research.

Benjamin B Policicchio¹, Ivona Pandrea¹, Cristian Apetrei¹

¹Center for Vaccine Research, University of Pittsburgh , Pittsburgh, PA , USA.

Frontiers in Immunology

|February 10, 2016

Summary

Finding a cure for human immunodeficiency virus (HIV) infection requires effective animal models. This review highlights key models and their contributions to HIV cure research, crucial for developing functional or sterilizing cures.

Keywords:

FIV HIV SIV animal models cure humanized mice non-human primates viral reservoir

More Related Videos

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

Related Experiment Videos

Last Updated: Mar 26, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

Area of Science:

Virology
Immunology
Infectious Diseases

Background:

The global human immunodeficiency virus (HIV) pandemic persists with no vaccine available.
Antiretroviral therapy (ART) manages HIV but does not eliminate the virus, necessitating a cure.
Developing a cure is essential to halt HIV spread and disease progression.

Purpose of the Study:

To review major animal models used in HIV cure research.
To evaluate the contributions of different animal models to understanding HIV persistence and eradication.
To identify ideal characteristics of animal models for assessing HIV cure strategies.

Main Methods:

Review of existing literature on animal models for HIV cure research.
Analysis of how different models recapitulate HIV pathogenesis and immune responses.
Assessment of model utility for evaluating functional and sterilizing cure strategies.

Main Results:

No single animal model perfectly replicates human HIV infection.
Various models, including non-human primates, mice, and felines, are tailored for specific research questions.
Each model offers unique insights into viral reservoirs and eradication strategies.

Conclusions:

Multiple, carefully selected animal models are indispensable tools for advancing HIV cure research.
Continued development and application of diverse animal models are vital for achieving a sterilizing or functional cure for HIV.
Animal models are central to evaluating novel therapeutic strategies aimed at eliminating HIV reservoirs.