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Updated: Mar 26, 2026

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Polymer-based disposable microneedle array with insertion assisted by vibrating motion.

F-W Lee1, W-H Hung1, C-W Ma1

  • 1Department of Mechanical Engineering, National Taiwan University , Taipei 10617, Taiwan.

Biomicrofluidics
|February 10, 2016
PubMed
Summary
This summary is machine-generated.

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This study introduces a novel microneedle array that uses mosquito-inspired vibrations for painless blood extraction. This disposable, low-cost device significantly reduces insertion force, offering a promising advancement in minimally invasive medical technology.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Microfabrication

Background:

  • Minimally invasive medical devices are crucial for patient comfort and reduced healthcare costs.
  • Existing microneedle technologies face challenges in insertion force and efficient fluid extraction.
  • Biocompatible polymers offer potential for low-cost, disposable medical devices.

Purpose of the Study:

  • To develop a disposable polymer-based microneedle array for blood extraction.
  • To investigate the use of mosquito proboscis-inspired vibrations for microneedle insertion.
  • To evaluate the device's performance in terms of insertion force, extraction rate, and mechanical stability.

Main Methods:

  • Fabrication of a high-aspect-ratio parylene microneedle array using a novel monolithic process.

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  • Integration of a piezoelectric actuator to generate vibrating motion for microneedle insertion.
  • Experimental measurement of insertion force, blood extraction flow rate, and buckling load.
  • Comparison of experimental results with analytical models.

    • Main Results:

    • Demonstrated a 40% reduction in insertion force with actuator-induced vibratory motion.
    • Achieved agreement between measured extraction flow rate and analytical predictions.
    • Evaluated buckling analyses to determine maximum load capacity of the microneedles.
    • Established the relationship between insertion force and vibration frequency.

    Conclusions:

    • The developed microneedle array offers a biocompatible, cost-effective, and efficient solution for blood extraction.
    • Mosquito-inspired vibratory insertion significantly reduces the force required for microneedle penetration.
    • The device shows potential for widespread application in diagnostics and minimally invasive procedures.