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Related Experiment Video

Updated: Mar 26, 2026

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking
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GRASP: A Multitasking Tether.

Catherine Rabouille1, Adam D Linstedt2

  • 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC UtrechtUtrecht, Netherlands; The Department of Cell Biology, University Medical Center UtrechtUtrecht, Netherlands.

Frontiers in Cell and Developmental Biology
|February 10, 2016
PubMed
Summary
This summary is machine-generated.

The Golgi reassembly stacking protein (GRASP) family acts as membrane tethers with diverse cellular roles. Recent findings reveal their function in Golgi ribbon formation, mitosis, ER exit sites, and unconventional secretion during cellular stress.

Keywords:
GRASPGolgi organizationPDZ domaincrystal structuremitosistethertrans-oligomerizationunconventional secretion

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Protein Structure and Function

Background:

  • The Golgi reassembly stacking protein (GRASP) family was initially identified as Golgi stacking factors.
  • GRASPs function as crucial membrane tethers involved in various cellular processes.
  • Previous reviews have summarized the known functions of GRASPs, necessitating an update.

Purpose of the Study:

  • To provide an updated overview of the latest findings on the diverse roles of the GRASP protein family.
  • To explore new insights into the mechanics of GRASP-mediated membrane tethering.
  • To highlight the functions of GRASPs beyond the Golgi apparatus.

Main Methods:

  • Analysis of recent crystal structures to understand GRASP-mediated tethering mechanics.
  • Review and synthesis of current literature on GRASP family functions.
  • Investigation of GRASP roles in Golgi ribbon dynamics, ER, and ER exit sites (ERES).

Main Results:

  • Recent crystal structures provide new insights into GRASP-mediated membrane tethering mechanisms.
  • GRASP65 and GRASP55 are directly implicated in mammalian Golgi ribbon formation and its disassembly during mitosis.
  • GRASPs exhibit roles outside the Golgi, including at the ER and ERES, and mediate unconventional secretion under cellular stress.

Conclusions:

  • GRASPs are versatile membrane tethers with critical roles in Golgi structure and dynamics.
  • GRASP functions extend to the ER and ERES, and they are involved in unconventional protein secretion pathways.
  • Understanding GRASP mechanisms offers insights into cellular organization, mitosis, and stress responses.