Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Torque Free Motion01:15

Torque Free Motion

903
The torque-free motion refers to the movement of a rigid body in space when no external torques are acting upon it. This type of motion can be observed in environments where there are no external forces or frictions, like in outer space. For example, a rotation of Mars in space is a torque-free motion. Mars is an axisymmetric object, meaning it has an axis of symmetry along which it rotates, designated as the z-axis. The rotating frame of reference is defined such that the center of mass of...
903
Multimachine Stability01:25

Multimachine Stability

621
Multimachine stability analysis is crucial for understanding the dynamics and stability of power systems with multiple synchronous machines. The objective is to solve the swing equations for a network of M machines connected to an N-bus power system.
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:
621
Drag Force and Terminal Speed01:18

Drag Force and Terminal Speed

3.6K
An interesting force in everyday life is the force of drag on an object when it is moving in a fluid. Like friction, the drag force always opposes the motion of an object. Unlike simple friction, the drag force is proportional to some function of the velocity of the object in that fluid. This functionality is complicated and depends upon the shape of the object, its size, its velocity, and the fluid it is in. For most large objects, such as cyclists, cars, and baseballs, that are not moving too...
3.6K
Maximum Power Transfer01:16

Maximum Power Transfer

1.1K
Numerous practical applications within engineering disciplines, such as telecommunications, necessitate optimizing power delivery to a connected load. This pursuit, however, entails inherent internal losses, which can either equal or exceed the power supplied to the load. The Thevenin equivalent circuit is helpful in finding the maximum power a linear circuit can deliver to a load. It is assumed in this context that the load resistance can be adjusted.
By substituting the entire circuit with...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Components of the Stress Assembly Sec Body Identified by Proximity Labeling.

Cells·2023
Same author

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells.

Journal of cell science·2022
Same author

Identification of the stress granule transcriptome via RNA-editing in single cells and <i>in vivo</i>.

Cell reports methods·2022
Same author

Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.

Journal of cell science·2021
Same author

Hherisomes, Hedgehog specialized recycling endosomes, are required for high level Hedgehog signaling and tissue growth.

Journal of cell science·2021
Same author

The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution.

Development (Cambridge, England)·2021

Related Experiment Video

Updated: Mar 26, 2026

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking
05:58

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking

Published on: August 29, 2018

9.4K

GRASP: A Multitasking Tether.

Catherine Rabouille1, Adam D Linstedt2

  • 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC UtrechtUtrecht, Netherlands; The Department of Cell Biology, University Medical Center UtrechtUtrecht, Netherlands.

Frontiers in Cell and Developmental Biology
|February 10, 2016
PubMed
Summary
This summary is machine-generated.

The Golgi reassembly stacking protein (GRASP) family acts as membrane tethers with diverse cellular roles. Recent findings reveal their function in Golgi ribbon formation, mitosis, ER exit sites, and unconventional secretion during cellular stress.

Keywords:
GRASPGolgi organizationPDZ domaincrystal structuremitosistethertrans-oligomerizationunconventional secretion

More Related Videos

Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace
09:11

Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace

Published on: August 8, 2019

6.1K
Touchscreen Sustained Attention Task SAT for Rats
09:31

Touchscreen Sustained Attention Task SAT for Rats

Published on: September 15, 2017

10.4K

Related Experiment Videos

Last Updated: Mar 26, 2026

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking
05:58

Using Rapid Serial Visual Presentation to Measure Set-Specific Capture, a Consequence of Distraction While Multitasking

Published on: August 29, 2018

9.4K
Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace
09:11

Design and Use of an Apparatus for Presenting Graspable Objects in 3D Workspace

Published on: August 8, 2019

6.1K
Touchscreen Sustained Attention Task SAT for Rats
09:31

Touchscreen Sustained Attention Task SAT for Rats

Published on: September 15, 2017

10.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Protein Structure and Function

Background:

  • The Golgi reassembly stacking protein (GRASP) family was initially identified as Golgi stacking factors.
  • GRASPs function as crucial membrane tethers involved in various cellular processes.
  • Previous reviews have summarized the known functions of GRASPs, necessitating an update.

Purpose of the Study:

  • To provide an updated overview of the latest findings on the diverse roles of the GRASP protein family.
  • To explore new insights into the mechanics of GRASP-mediated membrane tethering.
  • To highlight the functions of GRASPs beyond the Golgi apparatus.

Main Methods:

  • Analysis of recent crystal structures to understand GRASP-mediated tethering mechanics.
  • Review and synthesis of current literature on GRASP family functions.
  • Investigation of GRASP roles in Golgi ribbon dynamics, ER, and ER exit sites (ERES).

Main Results:

  • Recent crystal structures provide new insights into GRASP-mediated membrane tethering mechanisms.
  • GRASP65 and GRASP55 are directly implicated in mammalian Golgi ribbon formation and its disassembly during mitosis.
  • GRASPs exhibit roles outside the Golgi, including at the ER and ERES, and mediate unconventional secretion under cellular stress.

Conclusions:

  • GRASPs are versatile membrane tethers with critical roles in Golgi structure and dynamics.
  • GRASP functions extend to the ER and ERES, and they are involved in unconventional protein secretion pathways.
  • Understanding GRASP mechanisms offers insights into cellular organization, mitosis, and stress responses.