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Measles active and passive immunity in a worldwide perspective
Progress in Medical Virology. Fortschritte Der Medizinischen Virusforschung. Progres En Virologie Medicale
|January 1, 1989
Summary
Measles is highly infectious, requiring high antibody rates for herd immunity. Optimal vaccination timing, especially in developing nations, is crucial to overcome challenges and control the global spread of this disease.
Area of Science:
- Epidemiology
- Immunology
- Virology
Background:
- Measles is an extremely infectious viral disease with lifelong immunity conferred by relevant immune response components.
- Serological tests effectively measure measles immunity, indicating high antibody prevalence rates are necessary for herd protection.
Purpose of the Study:
- To elucidate the epidemiological factors determining measles transmission and control.
- To highlight the challenges and optimal strategies for achieving global measles herd immunity.
Main Methods:
- Analysis of serological data to assess antibody prevalence and correlate with measles immunity.
- Review of vaccination program data and epidemiological factors influencing vaccine effectiveness.
Main Results:
- Achieving herd immunity requires very high antibody prevalence, necessitating minimal immunization flaws and accurate record-keeping.
- Vaccination program failures in less-developed countries are the primary obstacle to worldwide measles control.
- Optimal vaccination age varies by community due to differences in passive immunity, antibody transfer, and infant antibody durability.
Conclusions:
- Effective measles control hinges on addressing vaccination procedural flaws and ensuring timely immunization after passive immunity wanes.
- Tailoring vaccination schedules to specific community needs is essential for protecting vulnerable populations.
- Global reduction of measles as a public health threat requires optimized vaccination strategies, particularly in resource-limited settings.