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Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial
Tadaharu Okazaki1, Takashi Asahara, Atsuyuki Yamataka
1*Department of Pediatric Surgery, Juntendo University Urayasu Hospital, Chiba, Japan†Department of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine‡Yakult Central Institute, Yakult Honsha Co, Ltd., Tokyo, Japan§Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan||Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Abstract:
The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.
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