Serum heart type fatty acid binding protein levels are not changed in hyperthyroidism

Area of Science:

• Cardiology
• Endocrinology
• Biochemistry

Background:

• Heart-type fatty acid binding protein (H-FABP) is a biomarker released during myocardial damage.
• H-FABP is linked to cardiac and endocrine disorders like prediabetes and metabolic syndrome.
• Hyperthyroidism is a known risk factor for cardiovascular diseases.

Purpose of the Study:

• To investigate the impact of hyperthyroidism on serum H-FABP levels.
• To determine if H-FABP correlates with thyroid hormone levels in hyperthyroid patients.

Main Methods:

• Serum H-FABP levels were measured in 46 hyperthyroid patients and 40 healthy controls.
• Sandwich enzyme-linked immunosorbent assay (ELISA) was used for H-FABP quantification.
• Correlation analysis was performed between H-FABP, fT3, fT4, and TSH levels.

Main Results:

• No significant difference in serum H-FABP levels was observed between hyperthyroid patients and controls (871±66 pg/mL vs. 816±66 pg/mL, P=0.56).
• No significant correlation was found between H-FABP levels and free triiodothyronine (fT3), free thyroxine (fT4), or thyroid-stimulating hormone (TSH) in either group.

Conclusions:

• Serum H-FABP levels are not altered in individuals with hyperthyroidism.
• H-FABP does not appear to be a reliable biomarker for thyroid dysfunction in this study population.