Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
6.5K
Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

2.1K
Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
2.1K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

1.0K
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.9K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K
Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal exposure to biosolids reshapes chemical burden and steroidogenic pathways to promote adipogenic differentiation in a sheep model.

Environment international·2026
Same author

Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.

The Journal of reproduction and development·2026
Same author

Early Pregnancy Targeted Exposome: Biological Response and Maternal BMI.

Toxics·2026
Same author

Microporous Immune-Isolating Capsule with Improved Diffusion for Restored Dynamic Bidirectional Hormone Signaling in a Murine Model of Premature Ovarian Insufficiency.

bioRxiv : the preprint server for biology·2026
Same author

Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model.

bioRxiv : the preprint server for biology·2026
Same author

Role of antioxidant vitamins in mitigating the health risks from environmental toxicant exposures: a narrative review.

Journal of the Endocrine Society·2026

Related Experiment Video

Updated: Mar 26, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.6K

Developmental Programming, a Pathway to Disease.

Vasantha Padmanabhan1, Rodolfo C Cardoso1, Muraly Puttabyatappa1

  • 1Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109-5718.

Endocrinology
|February 10, 2016
PubMed
Summary
This summary is machine-generated.

Perinatal insults, such as disease or stress, can alter fetal development, leading to adult diseases. This review explores common outcomes and pathways, identifying research gaps in developmental programming.

More Related Videos

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.7K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K

Related Experiment Videos

Last Updated: Mar 26, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.6K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.7K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.6K

Area of Science:

  • Developmental biology
  • Reproductive medicine
  • Pathology

Background:

  • Perinatal insults negatively impact fetal development, causing long-term health issues.
  • Insults include maternal disease, nutrition, stress, environmental exposures, and medical interventions.
  • These factors can lead to adult pathologies through altered developmental trajectories.

Purpose of the Study:

  • To review insults contributing to developmental programming.
  • To highlight common disease outcomes and converging mechanistic pathways.
  • To identify knowledge gaps and future research directions in the field.

Main Methods:

  • Literature review of studies on perinatal insults and developmental programming.
  • Analysis of commonalities in disease outcomes across different insults.
  • Examination of converging mechanistic pathways linking insults to pathologies.
  • Identification of current knowledge gaps and future research priorities.

Main Results:

  • Various perinatal insults converge on common mechanistic pathways.
  • Diverse insults can lead to similar long-term detrimental outcomes and adult pathologies.
  • Animal models are crucial for understanding underlying mechanisms of developmental programming.

Conclusions:

  • Understanding the common pathways of developmental programming is key to preventing adult diseases.
  • Further research is needed to address identified knowledge gaps.
  • Interventions targeting perinatal insults hold promise for improving long-term health outcomes.