Collaborative Total Synthesis: Routes to (±)-Hippolachnin A Enabled by Quadricyclane Cycloaddition and Late-Stage C-H
Monica E McCallum1, Christopher M Rasik2, John L Wood1
1Department of Chemistry and Biochemistry, Baylor University , One Bear Place 97348, Waco, Texas 76798, United States.
Abstract:
Described herein are synthetic efforts toward the synthesis of hippolachnin A. Two independently devised routes from the Brown and Wood groups allowed for the synthesis of hippolachnin A from the unusual starting material, quadricyclane, by harnessing the power of late-stage C-H oxidation. Collaborative union of the best features of the two routes allowed for preparation of the molecule with improved efficiency.
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