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Updated: Mar 26, 2026
Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
Stromal Cell-Derived Factor-1-3'A Polymorphism Favors HIV-1 Infection in Mexican Women
Jesús Salvador Velarde-Félix1, Silvestre Guadalupe Cázarez-Salazar, Sylvia Páz Díaz-Camacho
1Centro de Medicina Genx00F3;mica, Hospital General de Culiacx00E1;n x2018;Dr. Bernardo J. Gastx00E9;lum', Servicios de Salud de Sinaloa, Culiacx00E1;n, Mexico.
Objective:
To evaluate the association of the stromal cell-derived factor-1 (SDF1)-3'A polymorphism to HIV-1 infection, CD4+ T-lymphocyte counts, and viral load levels in a northwestern Mexican population.
Methods:
We investigated allele and genotype frequencies of the SDF1-3'A polymorphism in 634 mestizo individuals from Northwest Mexico (204 HIV-1 infected persons, 256 uninfected blood donors, and 174 uninfected female sex workers) by the PCR- RFLP method and compared them using a x(2) test. We also searched for correlations between the polymorphism and CD4+ T lymphocyte and viral load counts.
Results:
No differences were observed in the frequencies of alleles and genotypes between patients and controls. However, in female patients we found a significantly increased prevalence of both the A allele and GA heterozygous genotype compared to male patients, female blood donors, and female sex workers.
Conclusion:
Here we describe the association of the SDF1-3'A polymorphism with HIV-1 infection only in women, but not to CD4+ T-lymphocyte categories, viral load levels in patients with HIV-1/AIDS, or to exposure levels in female sex workers.
