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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Related Experiment Video

Updated: Mar 26, 2026

Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
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The Sertoli cell: Novel clinical potentiality.

Paschalia K Iliadou1, Christos Tsametis1, Athina Kaprara1

  • 1Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece.

Hormones (Athens, Greece)
|February 10, 2016
PubMed
Summary

Serum inhibin B and anti-Müllerian hormone (AMH) reflect Sertoli cell function in male fertility. Basal levels are informative, but stimulated levels and these markers do not improve sperm detection in azoospermia compared to FSH.

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Area of Science:

  • Reproductive Endocrinology
  • Spermatogenesis Biology
  • Male Infertility Diagnostics

Background:

  • Sertoli cells are crucial for spermatogenesis, regulating endocrine and paracrine functions.
  • Key Sertoli cell products, inhibin B and anti-Müllerian hormone (AMH), are proposed markers of Sertoli cell function and spermatogenesis.
  • Male subfertility diagnosis may benefit from assessing Sertoli cell function via serum hormone levels.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum inhibin B and AMH in male subfertility.
  • To determine if stimulated hormone levels provide additional clinical information.
  • To compare the predictive value of inhibin B and AMH with FSH for sperm retrieval in azoospermia.

Main Methods:

  • Analysis of basal and stimulated serum concentrations of inhibin B and AMH in subfertile men.
  • Correlation of hormone levels with testicular histology and cytology.
  • Comparison of inhibin B and AMH with Follicle-Stimulating Hormone (FSH) in predicting sperm presence in testicular sperm extraction (TESE)/fine needle aspiration (FNA) biopsy.

Main Results:

  • Serum inhibin B and AMH concentrations reflect Sertoli cell function and correlate with testicular histology.
  • Stimulated hormone levels did not offer significant additional clinical information compared to basal levels in subfertile men.
  • Inhibin B and AMH were not superior to FSH in predicting sperm presence in men with azoospermia undergoing TESE/FNA.

Conclusions:

  • Basal serum inhibin B and AMH are valuable indicators of Sertoli cell function in male subfertility.
  • Dynamic testing with stimulated hormone levels is not clinically advantageous.
  • FSH remains a more reliable predictor than inhibin B or AMH for sperm retrieval in azoospermic individuals.