Related Experiment Video

Updated: Mar 26, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.3K

New therapeutic options for skin and soft tissue infections

Matteo Bassetti1, Elda Righi, Alessia Carnelutti

  • 1Infectious Diseases Division, Santa Maria Misericordia Hospital, Udine, Italy.

Current Opinion in Infectious Diseases
|February 10, 2016
PubMed
Abstract

Insights

New antibiotics are emerging for methicillin-resistant Staphylococcus aureus (MRSA) complicated skin and soft tissue infections (cSSTIs). These novel treatments offer oral options and convenient dosing, improving patient management.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of complicated skin and soft tissue infections (cSSTIs) globally.
  • Vancomycin, the current standard, faces challenges including rising resistance, toxicity, and lack of oral options.
  • MRSA cSSTIs are linked to prolonged hospital stays, increased costs, and higher mortality rates.

Purpose of the Study:

  • To review recent advancements in antimicrobial therapies for MRSA cSSTIs.
  • To evaluate the potential benefits of new drugs in clinical practice.
  • To highlight emerging treatment options for healthcare providers.

Main Methods:

  • Literature review of recent developments in antimicrobial agents for MRSA cSSTIs.
  • Focus on approved and investigational drugs with activity against MRSA.
  • Analysis of drug characteristics relevant to clinical application.

Main Results:

  • Several new antimicrobials active against MRSA have been approved for cSSTI treatment.
  • Ongoing research is exploring additional therapeutic agents.
  • New drugs demonstrate promising features for managing MRSA cSSTIs.

Conclusions:

  • Newly approved drugs offer significant advantages for MRSA cSSTI management.
  • Key benefits include oral formulations and once-weekly IV regimens.
  • Broad-spectrum activity is another promising characteristic of these novel compounds.

More Related Videos

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics08:30

A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics

Published on: September 16, 2022

2.5K
Investigation of a Blue Light LED Device to Suppress Wound Pathogens Using a Collagen-Based Synthetic Skin Model08:11

Investigation of a Blue Light LED Device to Suppress Wound Pathogens Using a Collagen-Based Synthetic Skin Model

Published on: February 24, 2026

120

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
36
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
39
Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
6.5K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
920
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
329