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Published on: September 27, 2010
Altered hemispheric lateralization of white matter pathways in developmental dyslexia: Evidence from spherical
Jingjing Zhao1, Michel Thiebaut de Schotten2, Irene Altarelli3
1School of Psychology, Shaanxi Normal University and Shaanxi Provincial Key Laboratory of Behavior and Cognitive Neuroscience, Xi'an, China; Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Département d'Etudes Cognitives, Ecole Normale Supérieure, PSL Research University, Paris Cedex 05, France.
Abstract:
This study examines the structural integrity and the hemispheric lateralization patterns of four major association fiber pathways in a group of French dyslexic children and age-matched controls (from 9 to 14 years), using high angular diffusion imaging combined with spherical deconvolution tractography. Compared with age-matched controls, dyslexic children show increased hindrance-modulated oriented anisotropy (HMOA) in the right superior longitudinal fasciculus (SLF). They also show a reduced leftward asymmetry of the inferior fronto-occipital fasciculus (IFOF) and an increased rightward asymmetry of the second branch of the SLF (SLF II). The lateralization pattern of IFOF and SLF II also accounts for individual differences in dyslexic children's reading abilities. These data provide evidence for an abnormal lateralization of occipito-frontal and parieto-frontal pathways in developmental dyslexia.
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