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Cerebral microbleeds in idiopathic normal pressure hydrocephalus
Elias Johansson1, Khalid Ambarki2,3, Richard Birgander4
1Department of Pharmacology and Clinical Neuroscience, Norrlands Universitetssjukhus, Umeå University, S-901 85, Umeå, Sweden. elias.johansson@umu.se.
Fluids and Barriers of the CNS
|February 11, 2016
Summary
Cerebral microbleeds (CMB) are more common in patients with idiopathic normal pressure hydrocephalus (INPH). This suggests a vascular component may contribute to INPH pathophysiology.
Area of Science:
- Neurology
- Vascular Medicine
- Radiology
Background:
- Idiopathic normal pressure hydrocephalus (INPH) may involve vascular disease in its pathophysiology.
- Cerebral microbleeds (CMB) are potential markers of vascular disease.
- Investigating the association between CMB and INPH is crucial for understanding INPH etiology.
Purpose of the Study:
- To determine if cerebral microbleeds (CMB) are associated with idiopathic normal pressure hydrocephalus (INPH).
- To compare the prevalence and number of CMB between INPH patients and healthy controls.
Main Methods:
- A case-control study including 14 INPH patients and 41 healthy controls.
- Magnetic resonance imaging (MRI) with T2*-sequences was used to detect CMB.
- Two neuroradiologists reviewed MRI scans, and CMB prevalence was compared between groups.
Main Results:
- CMB were detected more frequently in the INPH group (43%) compared to healthy controls (10%) (p=0.01).
- INPH patients with CMB had a higher number of microbleeds (median 8) than controls (median 1) (p=0.005).
Conclusions:
- The findings support a vascular component in the pathophysiology of INPH.
- CMB may serve as a biomarker for vascular contributions to INPH.
