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Lithium in Medicine: Mechanisms of Action
Duarte Mota de Freitas1, Brian D Leverson2, Jesse L Goossens3
1Department of Chemistry and Biochemistry, Loyola University Chicago, 1068 West Sheridan Road, Chicago, IL, 60660, USA. dfreita@luc.edu.
Abstract:
In this chapter, we review the mechanism of action of lithium salts from a chemical perspective. A description on how lithium salts are used to treat mental illnesses, in particular bipolar disorder, and other disease states is provided. Emphasis is not placed on the genetics and the psychopharmacology of the ailments for which lithium salts have proven to be beneficial. Rather we highlight the application of chemical methodologies for the characterization of the cellular targets of lithium salts and their distribution in tissues.
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