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Related Experiment Videos

Transgenic mice as probes into complex systems.

D Hanahan1

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco 94143.

Science (New York, N.Y.)
|December 8, 1989
PubMed
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Transgenic mice allow scientists to study complex biological systems by altering genes. This genetic engineering approach provides new insights into development, function, and disease.

Area of Science:

  • Genetics
  • Developmental Biology
  • Immunology

Background:

  • Higher eukaryotes involve complex interactions between cells and organs.
  • Understanding cellular systems often requires studying disruptions in their function.
  • Transgenic mice offer a novel method for perturbing biological systems.

Purpose of the Study:

  • To explore the utility of transgenic mice for biological research.
  • To demonstrate how gene alteration in mice can reveal insights into complex systems.
  • To highlight the application of transgenic mouse models in studying development and disease.

Main Methods:

  • Stable genetic alteration of mouse embryos.
  • Introduction of novel or modified genes into the mouse genome.

Related Experiment Videos

  • Utilizing transgenic mice as a perturbation analysis tool.

    • Main Results:

    • Transgenic mice facilitate the study of gene function and biological processes.
    • This technology provides a powerful approach to investigate development, function, and malfunction.
    • Applications include research on immunological self-tolerance, oncogenes, and cancer.

    Conclusions:

    • Transgenic mice are invaluable for dissecting complex biological problems.
    • Gene transfer into mouse embryos offers significant opportunities for biological discovery.
    • This strategy enhances our understanding of development, cellular functions, and disease mechanisms.