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Infantile endogenous Candida endophthalmitis presenting as a cataract
T E Clinch1, J S Duker, R C Eagle
1Pediatric Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Survey of Ophthalmology
|September 1, 1989
Summary
A rare case of endogenous Candida endophthalmitis in an infant, presenting as a fungal abscess within the lens, was successfully treated with antifungal agents, preserving the affected eye.
Area of Science:
- Ophthalmology
- Mycology
- Pediatrics
Background:
- Endogenous endophthalmitis is often caused by Candida albicans, typically affecting immunocompromised adults with circulatory access.
- Predisposing factors in infants include prematurity, broad-spectrum antibiotics, and prior surgery.
- Candida endophthalmitis in infants is uncommon but serious.
Observation:
- A unilateral, sectoral lens opacity developed in an infant four months post-treatment for disseminated candidiasis.
- Clinical and histopathological examination confirmed a localized intralenticular fungal abscess with endophthalmitis.
Findings:
- Histopathology of aspirated lens material confirmed Candida albicans as the causative agent.
- Systemic antifungal therapy led to successful preservation of the infant's eye.
Implications:
- This case highlights the importance of considering fungal endophthalmitis in infants with a history of candidiasis.
- Early diagnosis and prompt systemic antifungal treatment are crucial for visual outcomes in pediatric Candida endophthalmitis.
- Further review of infant cases contributes to understanding this rare condition.