[The use of digoxin, lasix and finoptin in treating circulatory failure in hypertension]

Area of Science:

• Cardiology
• Geriatrics
• Pharmacology

Background:

• Essential hypertension is a common condition in middle-aged and elderly individuals.
• Circulatory failure (CF) complicates hypertension, particularly in the elderly.
• Age-related differences in neurohormonal systems may influence CF in hypertensive patients.

Purpose of the Study:

• To investigate age-related differences in the renin-angiotensin-aldosterone system (RAAS) and adenylate cyclase system in hypertensive patients with circulatory failure.
• To evaluate the effects of verapamil on hormonal levels, diuresis, and electrolyte balance in elderly hypertensive patients with CF.
• To establish a basis for combined therapeutic strategies in elderly patients with hypertensive circulatory failure.

Main Methods:

• Study included 118 middle-aged and elderly patients with essential hypertension and varying stages of circulatory failure.
• Assessed activity of the renin-angiotensin-aldosterone system and adenylate cyclase system.
• Administered verapamil as part of a complex therapeutic regimen.

Main Results:

• Elderly patients with CF exhibited lower RAAS activity compared to middle-aged patients.
• The adenylate cyclase system was activated earlier in elderly patients with CF.
• Verapamil administration led to stabilized or reduced plasma aldosterone levels.
• Verapamil induced prolonged diuresis and diminished acute electrolyte losses.

Conclusions:

• Age-related alterations in neurohormonal systems are evident in hypertensive patients with circulatory failure.
• Verapamil demonstrates beneficial effects in managing aldosterone levels, diuresis, and electrolyte balance in elderly patients.
• Combined therapy with digoxin, furosemide, and verapamil is a promising approach for treating elderly patients with hypertensive circulatory failure.