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Updated: Mar 26, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Cutaneous ulcerating nodules after many years of immunotherapy]
Hanneke Bouten1, Tamar E C Nijsten, Vincent Noordhoek Hegt
1Erasmus MC, Rotterdam.
Abstract:
A 40-year-old female patient was referred to the department of Dermatology with subcutaneous nodules and ulcers years after starting with immunotherapy injections (Purethal) for hay fever. The skin reaction appeared to be due to aluminium hydroxide, which is used as an adjuvant to many injections and vaccins. Aluminium hydroxide can cause delayed granulomatous contact dermatitis or foreign body reactions.
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