Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Copper-associated Chronic Hepatitis in Dogs.

The Veterinary clinics of North America. Small animal practice·2025
Same author

Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis.

Frontiers in veterinary science·2025
Same author

Genomic analyses identify 15 risk loci and reveal <i>HDAC2</i>, <i>SOX2-OT</i>, and <i>IGF2BP2</i> in a naturally occurring canine model of gastric cancer.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Serum miR-30b is increased in Labrador Retrievers with elevated hepatic copper levels.

Veterinary journal (London, England : 1997)·2025
Same author

Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands.

Veterinary sciences·2025
Same author

Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus.

PLoS genetics·2025

Related Experiment Video

Updated: Mar 26, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

2.1K

Canine Models for Copper Homeostasis Disorders.

Xiaoyan Wu1, Peter A J Leegwater2, Hille Fieten3

  • 1Department of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands. x.wu@uu.nl.

International Journal of Molecular Sciences
|February 11, 2016
PubMed
Summary

Canine genetics offers a powerful avenue for discovering new genes linked to copper metabolism disorders, mirroring human diseases like Wilson disease. Dogs also serve as valuable models for developing novel therapeutic strategies, including gene therapy.

Keywords:
ATP7AATP7BBedlington terrierCOMMD1Labrador retrieverMenkes diseaseWilson diseasecopper toxicosisgeneticsnutrition

More Related Videos

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

7.2K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

10.0K

Related Experiment Videos

Last Updated: Mar 26, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

2.1K
A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

7.2K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

10.0K

Area of Science:

  • Veterinary Genetics
  • Molecular Biology
  • Human Disease Modeling

Background:

  • Copper is vital for cellular functions, but hereditary defects cause severe disorders like Wilson disease and Menkes disease.
  • Wilson disease involves copper accumulation, leading to liver cirrhosis and neurological issues, with unexplained genotype-phenotype variability.
  • Canine copper-associated hepatitis shares similarities with human disorders, making dog populations valuable for genetic research.

Purpose of the Study:

  • To explore the potential of canine genetics in identifying novel genes implicated in copper metabolism disorders.
  • To highlight the utility of dogs as models for advancing treatment strategies for copper storage diseases.

Main Methods:

  • Review of existing literature on canine genetics and copper metabolism disorders.
  • Analysis of gene-mapping studies in affected dog populations.
  • Examination of canine organoid applications for disease modeling and gene therapy.

Main Results:

  • Canine populations provide a unique resource for discovering genes involved in copper metabolism.
  • Dogs' physiological characteristics make them suitable models for testing new therapeutic interventions.
  • Canine organoids are emerging as a tool for studying copper storage diseases and developing gene therapies.

Conclusions:

  • Canine genetics holds significant promise for unraveling the genetic basis of copper metabolism disorders.
  • The use of dogs and canine-derived models can accelerate the development of effective treatments for human copper storage diseases.