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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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Hepatotoxicity by Drugs: The Most Common Implicated Agents.
1Department of Internal Medicine, Division of Gastroenterology and Hepatology, The National University Hospital of Iceland and The Faculty of Medicine, The University of Iceland, 108 Reykjavik, Iceland. einarsb@landspitali.is.
International Journal of Molecular Sciences
|February 11, 2016
Summary
Idiosyncratic drug-induced liver injury (DILI) is a common adverse drug reaction. Amoxicillin-clavulanate is a frequent cause, while azathioprine and infliximab pose the highest risk for liver injury.
Area of Science:
- Pharmacovigilance
- Hepatology
- Drug Safety
Background:
- Idiosyncratic drug-induced liver injury (DILI) is an underreported adverse drug reaction.
- The LiverTox database provides public access to documented drug hepatotoxicity information.
- Analysis reveals a significant percentage of drugs have associated liver injury case reports.
Purpose of the Study:
- To analyze drug-induced liver injury data from the LiverTox database.
- To identify drugs with a high incidence of DILI.
- To assess the risk of DILI associated with specific medications.
Main Methods:
- Critical analysis of drug hepatotoxicity data from LiverTox.
- Review of prospective studies on DILI incidence.
- Identification of commonly implicated agents and high-risk drugs.
Main Results:
- 53% of analyzed drugs had at least one convincing report of liver injury.
- Only 48 drugs had over 50 reported DILI cases.
- Amoxicillin-clavulanate is the most common cause of DILI in prospective studies.
- Azathioprine and infliximab showed the highest risk for DILI in a recent study.
Conclusions:
- Drug-induced liver injury is a significant concern with widespread implications.
- Amoxicillin-clavulanate is a leading cause of DILI, affecting approximately 1 in 2300 users.
- Azathioprine and infliximab represent high-risk medications for DILI.
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