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Related Experiment Videos

[Intracellular peroxidation processes in chronic alcohol intoxication].

S V Pirozhkov, L F Panchenko

    Ukrainskii Biokhimicheskii Zhurnal (1978)
    |July 1, 1989
    PubMed
    Summary

    Chronic alcohol consumption induces lipid peroxidation, damaging cell membranes. This review details alcohol

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    Biomeditsinskaia khimiia·2018

    Area of Science:

    • Biochemistry
    • Toxicology
    • Cellular Biology

    Context:

    • Chronic alcohol administration is linked to cellular damage.
    • Lipid peroxidation (LP) is a key process in alcohol-induced cytotoxicity.
    • Understanding ethanol's impact on cellular defense mechanisms is crucial.

    Purpose:

    • To systematize existing literature on lipid peroxidation (LP) induced by chronic alcohol consumption.
    • To analyze the molecular mechanisms of LP stimulation in liver tissue due to ethanol.
    • To review changes in antioxidative enzymes and inhibitory protein factors during chronic alcoholization.

    Summary:

    • Chronic alcohol intake stimulates lipid peroxidation (LP), a major cause of cellular membrane damage.
    • Cytotoxicity arises from free radicals and LP decomposition products like malonic dialdehyde.
    • Antioxidative defense enzymes and inhibitory protein factors are altered by chronic alcohol exposure.
    • Peroxisomes play a role in alcohol-induced cardiomyopathy.

    Impact:

    • Provides a comprehensive overview of alcohol's effects on lipid peroxidation and cellular damage.
    • Highlights the role of specific molecules and cellular components in alcohol-related pathologies.
    • Informs future research on therapeutic strategies targeting alcohol-induced cellular injury.

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