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Formulation and Characterization of Bioactive Agent Containing Nanodisks
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Dextran-based Nanocarriers for Delivery of Bioactives
Rania A H Ishak, Rihab Osman1, Gehanne A S Awad
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University. African organization Unity Street, Cairo, Egypt. rihabosman@pharma.asu.edu.eg.
Current Pharmaceutical Design
|February 11, 2016
Summary
Dextran (DX), a natural polysaccharide, is a versatile nanocarrier for drug delivery. Its biocompatible properties and derivatization potential make it a key component in developing safe and effective nanodelivery systems.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Dextran (DX) is a natural polysaccharide produced via sucrose fermentation using DX sucrase.
- Purified DX undergoes processing to achieve specific molecular weights.
Purpose of the Study:
- To review the application of Dextran (DX) and its derivatives in drug delivery systems.
- To highlight the versatility of DX as a biocompatible nanocarrier platform.
Main Methods:
- Exploration of Dextran (DX) derivatization via its hydroxyl groups.
- Review of DX-based carriers and camouflaged particles for drug delivery.
- Analysis of ion-pairing, self-aggregate, protein, and drug conjugates.
Main Results:
- Dextran (DX) offers numerous sites for chemical modification, enabling the creation of functionalized glycoconjugates.
- DX derivatives are increasingly utilized as core decorations or carriers in advanced drug delivery systems.
- The review emphasizes the broad applicability of DX in constructing drug delivery vehicles.
Conclusions:
- Dextran (DX) possesses unique properties making it a promising nanocarrier.
- Its biocompatibility and versatility position it as a foundational element for safe nanodelivery systems.
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