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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
Published on: July 4, 2017
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Advances on Magnetic Nanocarriers Based on Natural Polymers
Rita Muzzalupo1, Lorena Tavano
1Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Arcavacata di Rende (CS)-Italy. rita.muzzalupo@unical.it.
Current Pharmaceutical Design
|February 11, 2016
Summary
Smart nanocarriers offer targeted drug delivery by responding to stimuli like magnetic fields. This review explores magnetic field-responsive nanodevices for precise drug and gene release in cancer therapy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Nanodevices are increasingly used for targeted delivery of drugs, peptides, and genes.
- Smart nanocarriers respond to internal or external stimuli for controlled release.
- Stimuli-responsive systems offer advantages over traditional biodegradable carriers for site-specific delivery.
Purpose of the Study:
- To review stimuli-responsive nanocarriers, focusing on magnetic field-responsive devices.
- To explore the concept, preparation, and applications of magnetic field-sensitive nanocarriers.
- To provide an overview of recent investigations in magnetic nanocarrier drug delivery.
Main Methods:
- Literature review of stimuli-responsive nanocarriers.
- Focus on magnetic field-responsive nanodevices derived from natural polymers.
- Analysis of preparation methods and drug delivery applications.
Main Results:
- Smart nanocarriers can release payloads in response to specific biological signals (e.g., pH, enzymes) or external triggers (e.g., magnetic fields).
- Magnetic field-responsive nanocarriers offer precise control over drug release kinetics.
- Natural polymers are utilized in the development of these magnetic nanodevices.
Conclusions:
- Magnetic field-responsive nanocarriers represent a promising approach for advanced drug delivery.
- These systems enable temporal and site-specific release, enhancing therapeutic efficacy.
- Further research into natural polymer-based magnetic nanocarriers is warranted for diverse applications.

