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[Regression of atherosclerosis lesions]
G Weber1, L Resi, P Tanganelli
1Atheroskleroseforschungszentrum, Institut für Pathologische Anatomie, Universität Siena, Italien.
Wiener Klinische Wochenschrift
|October 27, 1989
Summary
Advanced atherosclerotic vascular lesions can regress in both animals and humans. Non-invasive methods now allow reproducible documentation of lesion reduction, confirming this regression is possible.
Area of Science:
- Cardiovascular Research
- Vascular Biology
- Medical Imaging
Background:
- Atherosclerotic vascular lesions can be advanced and progressive.
- Regression of these lesions has been observed in various animal models.
- Evidence suggests lesion reduction is also possible in humans.
Purpose of the Study:
- To review the evidence for atherosclerotic lesion regression.
- To highlight the availability of validated non-invasive methods for documentation.
- To confirm the potential for luminal stenosis reduction in human patients.
Main Methods:
- Review of existing studies on lesion regression in animal models (dogs, pigs, rabbits, birds, monkeys).
- Analysis of well-controlled studies in selected human patient groups.
- Assessment of validated non-invasive morphological and morphometric methods.
Main Results:
- Regression of advanced atherosclerotic vascular lesions is well-documented across multiple animal species.
- Controlled human studies demonstrate that luminal stenosis reduction can occur.
- Reliable non-invasive methods exist for reproducible documentation of lesion reduction.
Conclusions:
- Atherosclerotic lesion regression is a documented phenomenon in both animal models and humans.
- Validated non-invasive techniques enable reproducible assessment of lesion regression.
- These findings support the potential for therapeutic interventions to reverse atherosclerotic progression.