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ApoCanD: Database of human apoptotic proteins in the context of cancer

Rahul Kumar1, Gajendra P S Raghava1

  • 1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.

Scientific Reports
|February 11, 2016
PubMed

Insights

A new database, ApoCanD, catalogs 82 apoptosis proteins crucial for understanding cancer progression. It reveals TP53 and MYD88 as frequently mutated cancer proteins, aiding cancer research.

Area of Science:

  • Molecular Biology
  • Genomics
  • Cancer Research

Background:

  • Apoptosis is a critical cellular process influencing cancer progression.
  • An inverse relationship exists between cancer progression and apoptosis rates.
  • Apoptosis proteins are key targets for developing novel anticancer therapies.

Purpose of the Study:

  • To develop a comprehensive database of apoptosis proteins in the context of cancer.
  • To provide crucial genomic and functional information for 82 apoptosis proteins.
  • To facilitate research in apoptosis and cancer by offering a centralized data resource.

Main Methods:

  • Compilation of data for 82 apoptosis proteins.
  • Inclusion of genomic status: mutation, copy number variation, and expression data.
  • Integration of gene essentiality, tertiary structure, sequence profiles, and post-translational modifications.

Main Results:

  • Development of the ApoCanD database, a dedicated resource for apoptosis proteins.
  • Identification of TP53 and MYD88 as the most frequently mutated proteins in cancer.
  • Inclusion of diverse data types to enhance utility for researchers.

Conclusions:

  • The ApoCanD database provides valuable information on apoptosis proteins and their role in cancer.
  • This resource is expected to significantly aid researchers in the fields of apoptosis and cancer.
  • A user-friendly web interface enhances accessibility and usability of the ApoCanD database.

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