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Association between high-sensitivity C-reactive protein and hyperuricemia.

Tuo Yang1, Xiang Ding1, Yi-Lun Wang1

  • 1Department of Orthopaedics, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, 410008, Hunan Province, China.

Rheumatology International
|February 11, 2016
PubMed
Summary

High-sensitivity C-reactive protein (hsCRP) is positively associated with a higher prevalence of hyperuricemia (HU). Elevated hsCRP levels significantly increase the odds of developing HU, particularly in women.

Keywords:
Cross-sectional studyHigh-sensitivity C-reactive proteinHyperuricemia

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Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Epidemiology

Background:

  • Inflammation, indicated by high-sensitivity C-reactive protein (hsCRP), may play a role in metabolic disorders.
  • Hyperuricemia (HU) is linked to various health conditions, and its association with inflammatory markers requires further investigation.

Purpose of the Study:

  • To investigate the cross-sectional association between hsCRP levels and the prevalence of HU.
  • To determine if hsCRP is an independent predictor of HU in a general population.

Main Methods:

  • A cross-sectional study involving 1935 subjects.
  • hsCRP measured by latex turbidity; uric acid by Beckman Coulter AU 5800.
  • Multivariable logistic regression analysis adjusted for confounding factors.

Main Results:

  • Increased odds of HU were observed with higher hsCRP quintiles (ORs ranging from 1.56 to 1.96, P<0.01 for trend).
  • A positive association was found in males (highest quintile OR 1.66, P=0.04).
  • Stronger associations were noted in females (fourth quintile OR 3.02, P=0.03; fifth quintile OR 3.66, P=0.01).

Conclusions:

  • Elevated hsCRP levels are significantly associated with an increased prevalence of hyperuricemia.
  • The association between hsCRP and HU is more pronounced in the female population.
  • hsCRP may serve as a potential indicator for hyperuricemia.