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Effect of lanosterol on human cataract nucleus
P Mahesh Shanmugam1, Aditya Barigali, Jayant Kadaskar
1Department of Vitreoretinal Services and Ocular Oncology, Sankara Eye Hospital, Kundalahalli Gate, Bengaluru, Karnataka, India.
Indian Journal of Ophthalmology
|February 11, 2016
Summary
Lanosterol did not reverse age-related cataracts in human lens nuclei. This study found no significant improvement in lens opacity after lanosterol treatment, indicating it
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Age-related cataracts are a leading cause of vision impairment.
- Lens opacity is a hallmark of cataract development.
- Lanosterol is a sterol involved in various biological processes.
Purpose of the Study:
- To investigate the potential of lanosterol in reversing age-related human cataractous lens nuclei.
- To assess the effect of lanosterol on lens opacity.
Main Methods:
- Human cataractous lens nuclei were obtained from surgery.
- Nuclei were immersed in 25 mM lanosterol or control solution for 6 days.
- Lens opacity changes were graded by masked observers.
Main Results:
- Both lanosterol-treated and control groups exhibited progression or no change in lens opacity.
- No regression of opacity was observed in the lanosterol group.
Conclusions:
- Lanosterol at 25 mM concentration did not reverse age-related cataractous changes in human lens nuclei.
- Further research may be needed to explore other potential therapeutic agents for cataracts.
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